RC3H2 Antibody, Biotin conjugated

Datasheet

Code	CSB-PA884510LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RC3H2 Polyclonal antibody

Uniprot No.

Q9HBD1

Target Names

RC3H2

Alternative Names

2900024N03Rik antibody; 9430019J22Rik antibody; D930043C02Rik antibody; FLJ20301 antibody; FLJ20713 antibody; Membrane associated DNA binding protein antibody; Membrane associated nucleic acid binding protein antibody; Membrane-associated nucleic acid-binding protein antibody; MGC52176 antibody; MNAB antibody; OTTHUMP00000022076 antibody; OTTHUMP00000022077 antibody; OTTMUSP00000013545 antibody; OTTMUSP00000013546 antibody; Rc3h2 antibody; RC3H2_HUMAN antibody; Ring finger and CCCH type domains 2 antibody; RING finger and CCCH type zinc finger domain containing protein 2 antibody; Ring finger and CCCH-type zinc finger domain-containing protein 2 antibody; ring finger and CCCH-type zinc finger domains 2 antibody; RING finger protein 164 antibody; RNF164 antibody; roquin-2 antibody; RP23-321B3.1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Roquin-2 protein (251-506AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation. miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression. Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains. Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains. Involved in the ubiquitination of MAP3K5. Able to interact with double-stranded RNA (dsRNA).

Gene References into Functions

Crystal structures, small-angle X-ray scattering, and E2 profiling revealed that while the two paralogs are highly homologous, RC3H2 and RC3H1 are different in their structures and functions. PMID: 26489670
Roquin-1 and roquin-2 proteins function redundantly in mRNA degradation. PMID: 26249698

Subcellular Location

Cytoplasm, P-body.

Tissue Specificity

Expressed in spleen, testis, ovary and small intestine.

Database Links

HGNC: 21461

OMIM: 615231

KEGG: hsa:54542

STRING: 9606.ENSP00000349783

UniGene: Hs.533499

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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